Colonoscopy with biopsy in Knoxville, TN costs $489 to $4,326. Here's every hospital's price.
3 hospitals in the Knoxville, TN metro area publish a cash price for colonoscopy with biopsy (CPT 45380). We read their files every month so you don't have to.
Across the Knoxville, TN metro area, 3 hospitals list a cash price for colonoscopy with biopsy (CPT 45380). The lowest is $489 at University Health System, INC, the median is $3,784 and the highest is $4,326 at Lafollette Medical Center. The most expensive hospital lists 8.8 times the cheapest for the same code.
The Knoxville, TN median of $3,784 is 159% above the national median of $1,459 across 780 US hospitals with a cash price for this code.
3 of these hospitals also publish the rates they negotiated with insurers, from $183 to $181,550. With insurance you pay a share of the negotiated rate, which is sometimes higher than the cash price; you may ask for the cash price instead.
The files behind these prices are dated between January 2026 and April 2026. 7 other hospitals in the metro area have no readable price for this code: some publish no file, some block automated reading, some leave the code out. They are listed below so you can call them.
Sorted by cash price
Hospital facility fee onlyKnoxville · 13 mi · File Jan 2026
Powell · 8 mi · File Apr 2026
La Follette · 24 mi · File Apr 2026
What's in the price
The hospital facility fee for CPT 45380. The doctor, anesthesia and lab work usually bill separately.
Cash vs. insured
Cash is what you pay without insurance. With insurance you pay a share of the negotiated rate, which can be higher than cash. You may ask for the cash price.
What to say on the phone
"I'd like the self-pay price for CPT 45380, in writing, and whether it covers facility, physician and anesthesia."
About colonoscopy with biopsy
CPT 45380 is a colonoscopy during which the doctor takes one or more tissue samples for the laboratory. It starts as an ordinary colonoscopy; the biopsy is decided during the exam, so most patients are scheduled for a diagnostic or screening colonoscopy and end up with this code instead.
What the price covers
The hospital's number is the facility fee for the endoscopy suite, sedation nursing, recovery and supplies, including the biopsy forceps. The gastroenterologist, the anesthesia provider and the pathologist who reads the sample bill separately. Pathology alone commonly adds $100 to $400 per specimen, so ask how many samples are expected.
How this relates to the other colonoscopy codes
- 45378: colonoscopy, nothing removed
- 45380: colonoscopy with biopsy (this page)
- 45385: colonoscopy with polyp removal by snare
A hospital's prices for the three usually sit close together, with biopsy and polyp removal slightly above the base code. If a hospital lists only one of them, use it as a guide for the others and confirm by phone.
Why prices vary
The range between hospitals in the same metro area is commonly several times. Ownership and size drive it more than geography: large systems and teaching hospitals list higher charges; community hospitals list lower ones. Cash prices are often far below the gross charge because most hospitals apply a fixed self-pay discount.
Questions to ask
- What is the self-pay price for 45380, and does it include pathology?
- Who bills for anesthesia, and what is their cash rate?
- If no biopsy is needed after all, will you bill 45378 instead?
Hospitals in Knoxville, TN without a price for this procedure
Listed so you know who to call. The reason is what we found on their website.
- Blount Memorial HospitalWebsite blocks automated reading
- East Tennessee Childrens HospitalWebsite blocks automated reading
- Fort Loudoun Medical CenterWebsite blocks automated reading
- Fort Sanders Regional Medical CenterWebsite blocks automated reading
- Methodist Medical Center of Oak RidgeWebsite blocks automated reading
- Parkwest Medical CenterWebsite blocks automated reading
- Roane Medical CenterWebsite blocks automated reading