Colonoscopy with biopsy in Harrisburg, PA costs $1,831 to $2,539. Here's every hospital's price.
3 hospitals in the Harrisburg-Carlisle, PA metro area publish a cash price for colonoscopy with biopsy (CPT 45380). We read their files every month so you don't have to.
Across the Harrisburg-Carlisle, PA metro area, 3 hospitals list a cash price for colonoscopy with biopsy (CPT 45380). The lowest is $1,831 at Penn State Health Holy Spirit Medical Center, the median is $2,412 and the highest is $2,539 at Milton S Hershey Medical Center.
The Harrisburg, PA median of $2,412 is 65% above the national median of $1,459 across 780 US hospitals with a cash price for this code.
5 of these hospitals also publish the rates they negotiated with insurers, from $286 to $6,825. With insurance you pay a share of the negotiated rate, which is sometimes higher than the cash price; you may ask for the cash price instead.
The files behind these prices are dated March 2026.
Sorted by cash price
Hospital facility fee onlyCamp Hill · 9 mi · File Mar 2026
Enola · 5 mi · File Mar 2026
Hershey · 23 mi · File Mar 2026
What's in the price
The hospital facility fee for CPT 45380. The doctor, anesthesia and lab work usually bill separately.
Cash vs. insured
Cash is what you pay without insurance. With insurance you pay a share of the negotiated rate, which can be higher than cash. You may ask for the cash price.
What to say on the phone
"I'd like the self-pay price for CPT 45380, in writing, and whether it covers facility, physician and anesthesia."
About colonoscopy with biopsy
CPT 45380 is a colonoscopy during which the doctor takes one or more tissue samples for the laboratory. It starts as an ordinary colonoscopy; the biopsy is decided during the exam, so most patients are scheduled for a diagnostic or screening colonoscopy and end up with this code instead.
What the price covers
The hospital's number is the facility fee for the endoscopy suite, sedation nursing, recovery and supplies, including the biopsy forceps. The gastroenterologist, the anesthesia provider and the pathologist who reads the sample bill separately. Pathology alone commonly adds $100 to $400 per specimen, so ask how many samples are expected.
How this relates to the other colonoscopy codes
- 45378: colonoscopy, nothing removed
- 45380: colonoscopy with biopsy (this page)
- 45385: colonoscopy with polyp removal by snare
A hospital's prices for the three usually sit close together, with biopsy and polyp removal slightly above the base code. If a hospital lists only one of them, use it as a guide for the others and confirm by phone.
Why prices vary
The range between hospitals in the same metro area is commonly several times. Ownership and size drive it more than geography: large systems and teaching hospitals list higher charges; community hospitals list lower ones. Cash prices are often far below the gross charge because most hospitals apply a fixed self-pay discount.
Questions to ask
- What is the self-pay price for 45380, and does it include pathology?
- Who bills for anesthesia, and what is their cash rate?
- If no biopsy is needed after all, will you bill 45378 instead?